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Combinatory treatments with the drug pairs remdesivir-angeloylgomisin O and remdesivir–schisandrin B show enhanced antiviral activity. (A) Synergy volumes for pairwise combination studies performed between remdesivir and each hit. Three-dimensional plot of synergy and antagonism at 99% confidence for the pairwise combination of remdesivir with angeloylgomisin O (B), schisandrin B (C), procyanidin (D), and oleanonic acid (E). The analysis was performed with MacSynergy II software.
