Figure 8.

Antiviral activity of angeloylgomisin O and schisandrin B against the SARS-CoV-2 variants. (A,B) Dose-dependent curves of both angeloylgomisin O and schisandrin B against the alpha variant (A) and beta variant (B). (C) The IC₅₀ values. Caco-2 cells were seeded in 96-well plates. After overnight incubation, cell monolayers were treated with hits; 1 h later, cells were infected with SARS-CoV-2 variants at an MOI of 0.5, followed by incubation for 24 h. The inhibition of SARS-CoV-2 variants was measured by using the IFA assay. Data were presented as the means ± SD from two or three independent experiments.