Figure 1.

The pathogenesis mechanism of cisplatin-induced anorexia and the mechanisms of action of herbal extracts. Intraperitoneal administration of cisplatin induces anorexia (red), whereas administration herbal extract increases appetite (blue). The brain, serum, small intestine, stomach, and spleen were affected by both cisplatin and herbal-extract treatments. Abbreviation: GHS-R1a, growth hormone secretagogue receptor type 1a; GSH-PX, glutathione peroxidase; 5-HIAA, 5-Hydroxyindole acetic acid; HMF, 3,3′,4′,5,6,7,8-heptamethoxyflavone; 5-HT, 5-Hydroxytryptamine (serotonin); 5-HTR, 5-HT receptor; IFN-γ, interferon-γ; MAO-A, monoamine oxidase A; MDA, malonaldehyde; SERT, serotonin reuptake transporter; SOD, superoxide dismutase; TNF-α, tumor necrosis factor-α; TPH, tryptophan hydroxylase.