Table 1.

Relationship between p53 mutations and tumor microenvironment.

p53 Mutation	Cancer Type	Change in Microenvironment	Reference
R273H	Pancreatic ductal carcinoma	Release of mutp53-containing	[74]
		EVs.
	Colon carcinoma	Enhancement of CSC expansion.	[75]
	Non-small cell lung carcinoma	Pro-invasive microenvironment and	[76,77]
		ECM regulation.
R175H	Non-small cell lung carcinoma	Pro-invasive microenvironment.	[76]
V157F	Pancreatic ductal carcinoma	Release of mutp53-containing	[74]
		EVs.
R249S	Pancreatic ductal carcinoma	Release of mutp53-containing	[74]
		EVs.
P309S	Colon carcinoma	Enhancement of CSC expansion.	[75]
R248W	Colon carcinoma	Enhancement of CSC expansion.	[75]
R246I	Non-small cell lung carcinoma	ECM regulation.	[77]
R248	Ovarian cancer	Increased adhesion to mesothelial	[78]
		cells.