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. 2022 Feb 5;20(2):125. doi: 10.3390/md20020125

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of Sdy-1 on β-catenin gene synthesis in HepG2 and HeLa cells. (a) HepG2 and (b) HeLa cells were treated with 10, 25, or 50 nM Sdy-1 for 24 h. Cytoplasmic and nuclear lysates from HepG2 and HeLa cells, β-catenin levels were determined by Western blot analysis. (c) The mRNA expression of β-catenin after Sdy-1 treatment was detected by real-time quantitative PCR. Sdy-1 markedly reduced transcription of β-catenin in a dose-dependent manner. Data are expressed as mean ± SD of three independent tests. * p < 0.05, ** p < 0.01 vs. the control group.

Effect of Sdy-1 on β-catenin gene synthesis in HepG2 and HeLa cells. (a) HepG2 and (b) HeLa cells were treated with 10, 25, or 50 nM Sdy-1 for 24 h. Cytoplasmic and nuclear lysates from HepG2 and HeLa cells, β-catenin levels were determined by Western blot analysis. (c) The mRNA expression of β-catenin after Sdy-1 treatment was detected by real-time quantitative PCR. Sdy-1 markedly reduced transcription of β-catenin in a dose-dependent manner. Data are expressed as mean ± SD of three independent tests. * p < 0.05, ** p < 0.01 vs. the control group.