Table 10.

Second-line intravenous therapy as an alternative to NSAIDs in acute headache unresponsive to first-line therapy.

Drug	Dose	Maximum Dose
INTRAVENOUS HYDRATION + PROCHLORPERAZINE + IV KETOROLAC	0.15 mg/kg 0.5 mg/kg	10 mg 30 mg
SUMATRIPTAN	3–6 mg NS	20 mg in 24 h
METOCLOPRAMIDE	0.2 mg/kg IV	10 mg
DIHYDROERGOTAMINE (DHE)	0.5 mg in 3 min IV

IV = intravenous; NS = nasal spray.