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. 2022 Feb 4;14(2):362. doi: 10.3390/pharmaceutics14020362

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Schematic representation of the mechanism of action of Cy-SS-MTX theranostic agent in the presence of glutathione (GSH); (b) presentation of the positive increase in photoacoustic signal of Cy-SS-MTX in the presence of GSH; (c) PA intensity of Cy-SS-MTX and responses of Cy-SS-MTX to GSH upon excitation at 680 and 808 nm, respectively, in varying concentrations; (d) the corresponding illustrations of PAI; and (e) in vivo photoacoustic imaging of tumor-bearing mice at 0/0.5/1/4/8/24 h after intravenous injection. Adapted from [115], Frontiers in Materials, 2018.