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. 2022 Feb 16;23(4):2201. doi: 10.3390/ijms23042201

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of losartan, mirabegron, and their combination on DOXO-induced histologic changes at week 9. Values are presented as mean ± S.E.M., * p < 0.05 vs. control group, # p < 0.05 vs. DOXO-only group (n = 6–9, one-way ANOVA in the case of cardiomyocyte cross-sectional area and ANOVA on ranks in the case of LV collagen, Holm-Sidak post hoc test). (a) Representative hematoxylin-eosin (HE)-stained sections at 40× and 100× magnifications, (b) cardiomyocyte cross-sectional area, (c) representative picrosirius red and fast green (PSFG)-stained sections at 20× magnification, (d) left ventricular (LV) collagen content. DOXO: doxorubicin, L: losartan, M: mirabegron.