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. 2022 Jan 22;15(2):129. doi: 10.3390/ph15020129

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Bioavailability radar of Artemisia campestris selected compounds (A: artemisinin, B: acetate of dihydroartemisinin, C: artemisinic aldehyde, D: deoxyartemisinin, and E: dihydroartemisinin) based on physicochemical indices ideal for oral bioavailability. LIPO, Lipophilicity: −0.7 < XLOGP3 < þ 5; SIZE, Molecular size: 150 g/mol < mol. wt. < 500 g/mol; POLA, Polarity: 20 Å2 < TPSA <130 Å2; INSO, Insolubility: 0 < Log S (ESOL) < 6; INSA, Insaturation: 0.25 < Fraction Csp3 < 1; FLEX, Flexibility: 0 < Number of rotatable bonds < 9. The colored zone is the suitable physicochemical space for oral bioavailability. Note: the selected compounds stand in the pink area, which indicates the ideal and suitable compounds’ bioavailability.