Table 3.
Univariable and multivariable analysis of factors associated with a lower HDL cholesterol level.
| Univariable Analysis | Multivariable Analysis | ||||
|---|---|---|---|---|---|
| Parameter | HDL | p | O.R. [95% CI] | p | |
| ≤24.5 (n = 46) | >24.5 (n = 81) | ||||
| Age (years), median [IQR] | 64.5 [44–72] | 68 [57–72] | 0.343 | ||
| Sex, n (%) | 0.844 | ||||
| M | 32 (69.5) | 54 (66.6) | |||
| F | 14 (30.4) | 27 (33.3) | |||
| Fever, (°C), median [IQR] | 39 [38–39.5] | 39 [38–39] | 0.347 | ||
| CRP, (mg/dL), median [IQR] | 11 [4.7–18.1] | 6.5 [2.3–11.5] | 0.004 | 0.986 [0.944–1.031] | 0.543 |
| ESR, (mm/h), median [IQR] | 60 [34–77] | 54 [37–81] | 0.709 | ||
| Neutrophils, (cells/µL), median [IQR] | 11,295 [6152–16,700] | 7590 [5145–10,820] | 0.004 | 1.000 [1.000–1.000] | 0.221 |
| Creatinine, (mg/dL), median [IQR] | 1.2 [0.7–2.1] | 0.9 [0.8–1.2] | 0.062 | ||
| eGFR MDRD, (mL/min), median [IQR] | 60.5 [33–123.2] | 74 [61–95.5] | 0.156 | ||
| Glycemia, (mg/dL), median [IQR] | 109 [86–168] | 110 [91.5–135] | 0.49 | ||
| Cholesterol, (mg/dL), median [IQR] | |||||
| Total | 100.5 [76.5–122.7] | 145 [115.5–179.5] | 0 | ||
| LDL | 55 [35.4–69.8] | 86 [58.9–103.6] | 0 | ||
| Triglycerides, (mg/dL), median [IQR] | 142 [113.5–198] | 108 [88.5–141] | 0 | 1.011 [1.003–1.019] | 0.008 |
| Left sided IE, n (%) | 27 (58.7) | 64 (79.0) | 0.08 | ||
| Right sided IE, n (%) | 16 (34.8) | 15 (18.5) | |||
| Etiology, n (%) | 0.026 | 0.664 [0.444–0.993] | 0.046 | ||
| S. aureus | 14 (35.9) | 11 (15.2) | |||
| Enterococcus spp. | 9 (23.1) | 13 (18.1) | |||
| Streptococcus spp. | 3 (7.7) | 22 (30.6) | |||
| CoNS | 10 (25.6) | 20 (27.7) | |||
| Other pathogens | 3 (7.7) | 6 (8.4) | |||
| Diabetes mellitus, n (%) | 11 (23.9) | 17 (20.9) | 0.824 | ||
| Chronic heart failure, n (%) | 9 (19.5) | 20 (24.6) | 0.661 | ||
| Chronic kidney disease, n (%) | 10 (21.7) | 6 (7.4) | 0.026 | 4.442 [0.885–22.292] | 0.07 |
| Ischemic heart disease, n (%) | 13 (28.2) | 19 (23.4) | 0.674 | ||
| Cardiac surgery, n (%) | 27 (58.6) | 52 (64.1) | 0.33 | ||
| Vegetation size, (mm), median [IQR] | 18 [10–20] | 13 [10–19] | 0.106 | ||
| Embolism, n (%) | 16 (34.7) | 16 (19.7) | 0.088 | ||
| In-hospital mortality, n (%) | 14 (30.4) | 6 (7.4) | 0.002 | 9.292 [2.059–41.934] | 0.004 |
Data are expressed as number and percentage or median and interquartile range (IQR). CoNS, coagulase-negative Staphylococci; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; ESR, erythrocyte sedimentation rate; HDL, high-density lipoprotein; IQR, interquartile range; LDL, low-density lipoprotein; MDRD, modification of diet in renal disease.