Table 1.

Optimization of the reaction parameters for copper-mediated radiofluorination of (S)-35.

Entry	(S)-35 (µmol)	Cu Complex	Eq. Cu Complex 1	Eq. of Pyrizdine 1	RCY 2 (%)
1	10	Cu(OTf)2	2	15	5
2	10	Cu(OTf)2	4	15	28
3	20	Cu(OTf)2	2	2.5	7
4	20	Cu(OTf)2	2	4	30
5	20	Cu(OTf)2	2	5	31
6	20	Cu(OTf)2	2	7.5	24
7	20	Cu(OTf)2	2	15	11
8	20	Cu(OTf)2	2	25	9
9	20	Cu(OTf)2	4	5	15
10	20	Cu(OTf)2	4	7.5	18
11	20	Cu(OTf)2	4	15	12
12	20	Cu(OTf)2	4	25	5
13	30	Cu(OTf)2	2	5	27
14	30	Cu(OTf)2	4	15	12
15	20	Cu(OTf)2(py)4	1	0	37
16	20	Cu(OTf)2(py)4	1.5	0	54
17	20	Cu(OTf)2(py)4	2	0	41
18	20	Cu(OTf)2(py)4	2.5	0	36

¹ related to the molar amount of precursor. ² determined by radio-TLC analyses of the crude reaction mixture after 10 min of reaction time at 110 °C.