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. Author manuscript; available in PMC: 2022 Feb 25.
Published in final edited form as: J Med Chem. 2020 Nov 17;63(23):14951–14978. doi: 10.1021/acs.jmedchem.0c01464

Figure 1.

Figure 1.

Initial non-covalent binding specificity (Ki = koff/kon) of a covalent inhibitor to a target protein and second order rate constant (kinact) for covalent bond formation.