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. Author manuscript; available in PMC: 2022 Feb 25.
Published in final edited form as: J Med Chem. 2020 Nov 17;63(23):14951–14978. doi: 10.1021/acs.jmedchem.0c01464

Figure 2.

Figure 2.

Guaianolide analogs: potent inhibitors of NF-κB signaling. (A) Example structure of a guaianolide analog, where the series varies by the substitution at the C14 position, and the stereochemistry at the C6, C7, and C8 positions. (B) Retrosynthetic analysis suggests that lactam 3 can be prepared by an allenic Pauson–Khand reaction (APKR) of allene-yne 5 based upon precedent established for the preparation of 2 from 4.