Table 2.

APKR with α-Methylene-γ-lactam Tether.

Entry	Allene-yne	R1	R2	APKR yield %a
1	24a	Ph	H	45 (72)b,c
2	25a	TIPS	H	46 (46)b,d
3	26	H	H	47 (53)b
4	30a	Ph	Me	48 (75)e
5	37	Ph	Ph	49 (67)b,c
6	38	Ph	4-CN-C6H4	50 (72)e
7	39	Ph	4-CF3-C6H4	51 (70)b
8	40	Ph	4-OMe-C6H4	52 (77)b
9	42	Ph	2-thiophenyl	53 (67)b
10	43	Ph	Ts	54 (71)b,c
11	44	Ph	boc	55 (40)b,c

^aDropwise addition of allene-yne to rhodium catalyst over 1 h, then heated for an additional 30 min

^bAverage yield for two runs

^cSimilar yields were obtained when allene-yne was added in a single portion.

^dReaction was heated for 3 h upon completion of allene-yne addition

^eYield based upon one run.