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. Author manuscript; available in PMC: 2022 Feb 25.
Published in final edited form as: J Med Chem. 2020 Nov 17;63(23):14951–14978. doi: 10.1021/acs.jmedchem.0c01464

Table 4. Cellular Toxicity of Lactams to Vero Cells.

Cellular viabilities were measured by Alamar Blue viability dye. IC50 values shown are mean ± S.D. for n ≥ 3 biological replicates.

Compound IC50 (μM)
47 > 200
49 21.9 ± 1.6
51 15.7 ± 1.2
52 44.0 ± 5.7
60 7.8 ± 0.9
S17 6.2 ± 1.0