TABLE 1.
Current WHO classification of meningioma and frequently associated molecular alterations
| Meningioma subtype | CNS WHO Grade | Frequent molecular alteration | Typical Methylation group (14) |
|---|---|---|---|
| (Meningioma, NOS) | |||
| Meningothelial | 1 | AKT1/TRAF7, SMO | Ben‐2 |
| Fibrous | 1 | NF2, 22q del | Ben‐1 |
| Transitional | 1 | NF2, 22q del | Ben‐1 |
| Psammomatous | 1 | NF2, 22q del | Ben‐1 |
| Angiomatous | 1 | Trisomy 5 | Ben‐3 |
| Microcystic | 1 | Trisomy 5 | Ben‐3 |
| Secretory | 1 | KLF4/TRAF7 | Ben‐2 |
| Lymphoplasmacyte‐rich | 1 | (None) | |
| Metaplastic | 1 | Trisomy 5 | Ben‐3 |
| Chordoid | 2 | Various | |
| Clear cell | 2 | SMARCE1 | Separate group |
| Rhabdoid | 2 | BAP1 | mal (if “true” rhabdoid) |
| Papillary | 2 | PBRM1 | mal (if “true” papillary) |
| Atypical | 2 | Enriched for int‐A/int‐B | |
| Brain invasive | 2 | ||
| Anaplastic | 3 | CDKN2A/B, TERT | mal |