TABLE 1.
Post‐mortem motor cortex sample information
| Sex | Onset site | Genotype | fALS | Protein aggregates | FTD | Age at disease onset | Age of death | PMI | |
|---|---|---|---|---|---|---|---|---|---|
| Control 1 | M | N/A | N/A | N/A | N/A | N/A | N/A | 82 | 50 |
| Control 2 | M | N/A | N/A | N/A | N/A | N/A | N/A | 66 | 81 |
| Control 3 | M | N/A | N/A | N/A | N/A | N/A | N/A | 49 | 45 |
| Control 4 | F | N/A | N/A | N/A | N/A | N/A | N/A | 58 | 18 |
| Control 5 | M | N/A | N/A | N/A | N/A | N/A | N/A | 60 | 14 |
| Control 6 | F | N/A | N/A | N/A | N/A | N/A | N/A | 77 | 72 |
| Control 7 | F | N/A | N/A | N/A | N/A | N/A | N/A | 90 | 24 |
| Control 8 | F | N/A | N/A | N/A | N/A | N/A | N/A | 79 | Unknown |
| Control 9 | F | N/A | N/A | N/A | N/A | N/A | N/A | 57 | 13 |
| Control 10 | F | N/A | N/A | N/A | N/A | N/A | N/A | 60 | 15 |
| Control 11 | M | N/A | N/A | N/A | N/A | N/A | N/A | 63 | 16 |
| Control 12 | M | N/A | N/A | N/A | N/A | N/A | N/A | 86 | 10 |
| Control 13 | F | N/A | N/A | N/A | N/A | N/A | N/A | 73 | 20 |
| Control 14 | M | N/A | N/A | N/A | N/A | N/A | N/A | 92 | 23 |
| Control 15 | F | N/A | N/A | N/A | N/A | N/A | N/A | 52 | 10 |
| Control 16 | M | N/A | N/A | N/A | N/A | N/A | N/A | 55 | 19 |
| Control 17 | F | N/A | N/A | N/A | N/A | N/A | N/A | 85 | 24 |
| Control 18 | F | N/A | N/A | N/A | N/A | N/A | N/A | >90 | 45 |
| Control 19 | F | N/A | N/A | N/A | N/A | N/A | N/A | 79 | 9 |
| Control 20 | M | N/A | N/A | N/A | N/A | N/A | N/A | >90 | 23 |
| Control 21 | F | N/A | N/A | N/A | N/A | N/A | N/A | >90 | 24 |
| Control 2 | M | N/A | N/A | N/A | N/A | N/A | N/A | 89 | 36 |
| Control 23 | M | N/A | N/A | N/A | N/A | N/A | N/A | 70 | 56 |
| Control 24 | M | N/A | N/A | N/A | N/A | N/A | N/A | >90 | 86 |
| Control 25 | M | N/A | N/A | N/A | N/A | N/A | N/A | 66 | 71 |
| ALS 1 | M | Limb | Unknown | Unknown | TDP43 | No | 57 | 62 | 46 |
| ALS 2 | F | Limb | Unknown | Unknown | TDP43; Ubiquitin | No | 22 | 34 | 65 |
| ALS 3 | M | Bulbar | C9ORF72 | Yes | TDP43; Ubiquitin | No | 55 | 61 | 77 |
| ALS 5 | M | Limb | Unknown | No | TDP43 | No | 58 | 66 | 43 |
| ALS 6 | M | Limb | Unknown | No | TDP43 | No | 62 | 68 | 43 |
| ALS 7 | M | Limb | Unknown | No | TDP43 | No | 54 | 78 | 35 |
| ALS 8 | M | Limb | Unknown | Unknown | TDP43; tau | No | 74 | 85 | 38 |
| ALS 9 | F | Limb | Unknown | Unknown | TDP43 | No | 64 | 70 | 30 |
| ALS 10 | M | Unknown | Unknown | Unknown | TDP43 | No | Unknown | 58 | 30 |
| ALS 11 | M | Limb | Unknown | Unknown | TDP43 | No | Unknown | 62 | 24 |
| ALS 12 | M | Limb | C9ORF72 | Yes | TDP43 | No | 57 | 61 | 22 |
| ALS 13 | M | Unknown | Unknown | Unknown | TDP43 | No | Unknown | 64 | 20 |
| ALS 14 | M | Limb | Unknown | Unknown | TDP43 | No | 41 | 62 | 24 |
| ALS 15 | F | Limb | Unknown | Unknown | Ubiquitin | No | 65 | 66 | 24 |
| ALS 16 | F | Bulbar | Unknown | Unknown | TDP43 | No | 46 | 49 | 25 |
| ALS 17 | F | Limb | Unknown | Unknown | TDP43 | Yes | 52 | 53 | 30 |
| ALS 18 | M | Limb | Unknown | No | Unknown | Unknown | 75 | 79 | Unknown |
| ALS 19 | M | Unknown | Unknown | Unknown | Unknown | Unknown | Unknown | 69 | 24 |
| ALS 20 | M | Bulbar | Unknown | Unknown | Unknown | Yes | 58 | 61 | 24 |
| ALS 21 | M | Bulbar | Unknown | Unknown | Unknown | No | 79 | 81 | 4 |
| ALS 22 | M | Limb | Unknown | Unknown | Unknown | Unknown | 75 | 76 | 14 |
| ALS 23 | F | Bulbar | Unknown | No | Unknown | No | 76 | Unknown | 24 |
| ALS 24 | M | Unknown | Unknown | Unknown | TDP43 | Unknown | Unknown | 58 | 30 |
| ALS 25 | F | Unknown | C9ORF72 | Unknown | TDP43 | Unknown | Unknown | 67 | 19 |
| ALS 26 | M | Limb | Unknown | No | Unknown | No | 53 | 53 | 24 |
| ALS 27 | M | Limb | Unknown | Unknown | Unknown | No | 59 | 60 | 19 |
| ALS 28 | M | Limb | Unknown | Unknown | Unknown | No | 57 | 60 | 22 |
| ALS 29 | M | Limb | Unknown | No | TDP43 | No | 49 | 51 | 24 |
| ALS 30 | M | Limb | Unknown | No | TDP43; Ubiquitin | No | 58 | 62 | 24 |
| ALS 31 | F | Limb | Unknown | No | TDP43 | No | 90 | 91 | 33 |
| ALS 32 | F | Bulbar | Unknown | No | Unknown | No | 50 | 52 | 28 |
| ALS 33 | F | Bulbar | C9ORF72 | Unknown | TDP43 | No | 54 | 56 | Unknown |
| ALS 34 | F | Bulbar | C9ORF72 | Unknown | TDP43 | No | 49 | 58 | 48 |
| ALS 35 | M | Bulbar | Unknown | No | Unknown | No | 53 | 55 | 36 |
| ALS 36 | M | Limb | Unknown | No | Unknown | No | 50 | 61 | 8 |
| ALS 37 | F | Limb | Unknown | No | Unknown | No | 63 | 65 | 36 |
| ALS 38 | M | Limb | Unknown | No | Unknown | No | 59 | 61 | 12 |
| ALS 39 | F | Limb | Unknown | Unknown | Unknown | Unknown | 66 | 68 | 20 |
| ALS 40 | M | Bulbar | Unknown | Unknown | TDP43 | No | 54 | 57 | 24 |
| ALS 41 | F | Bulbar | Unknown | No | TDP43 | No | 47 | 54 | 24 |
| ALS 42 | F | Bulbar | C9ORF72 | Possible | TDP43 | Yes | Unknown | 59 | 20 |
| ALS 43 | F | Unknown | Unknown | Unknown | TDP43 | Unknown | Unknown | 70 | Unknown |
| ALS 44 | M | Bulbar | Unknown | Unknown | TDP43 | No | Unknown | 70 | 18 |
| ALS 45 | M | Limb | Unknown | No | TDP43 | No | 50 | 55 | 12 |
| ALS 46 | F | Bulbar | Unknown | No | TDP43 | No | 73 | 75 | 56 |
| ALS 47 | M | Bulbar | Unknown | No | TDP43 | No | 70 | 71 | 14 |
| ALS 48 | M | Bulbar | Unknown | No | TDP43 | No | 62 | 70 | 28 |
| ALS 49 | M | Limb | Unknown | No | TPD43; Ubiquitin | No | 68 | 73 | 28 |
| ALS 50 | M | Limb | C9ORF72 | No | TPD43; Ubiquitin | No | 58 | 65 | 80 |
| ALS 51 | M | Limb | C9ORF72 | Possible | TDP43 | No | 40 | 50 | 36 |
| ALS 52 | M | Bulbar | Unknown | Unknown | TDP43 | No | 69 | 73 | 45 |