Table 2.
Characteristics of SARS-CoV-2 Variants of Concern (VOC).
| Linage | Named | First Identified | WHO Label | Spike Protein Substitutions |
|---|---|---|---|---|
| B.1.1.7 | 501.Y.V1 | United Kingdom | Alpha (α) | 69del, 70del, 144del, (E484K*), (S494P*), N501Y, A570D, D614G, P681H, T716I, S982A, D1118H (K1191N*) |
| B.1.351 | 501.V2 | South Africa | Beta (β) | D80A, D215G, 241del, 242del, 243del, K417N, E484K, N501Y, D614G, A701V |
| B.1.617.2 | 478K | India | Delta (δ) | T19R, (G142D*), 156del, 157del, R158G, L452R, T478K, D614G, P681R, D950N |
| P.1 | 501Y.V3 | Japan/Brazil (Manaus) | Gamma (γ) | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I |
| B.1.1.529 | 21K | South Africa | Omicron (Ὸ) | A67V, del69-70, T95I, del142-144, Y145D, del211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F |
(*) = detected in some sequences but not all. Adapted from CDC: SARS-CoV-2 Variant Classifications and Definitions (https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html#Interest, accessed on 19 December 2021).