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Pharmacokinetic and affinity data for intravitreal anti-VEGFs.
| Drug | Ranibizumab | Bevacizumab | Aflibercept | Brolucizumab |
|---|---|---|---|---|
| Intravitreal half-life (days) | 7.19 | 9.82 | 9.1 | 5.1 |
| Dose (mg) | 0.5 | 1.25 | 2 | 6 |
| Dissociation constant for VEGF-A165 (pM) |
46 | 58 | 0.49 | 28.4 |
| Molecular mass (kDa) |
48 | 149 | 115 | 26 |
Legend: kDa: kilodaltons; mg: milligrams; pM: picomolar; VEGF: vascular endothelial growth factor.
