Table 1.
Effects of PRF on body weight food intake and organ weights in HFD-induced obese mice.
| ND | HFD | OR | PRF 50 | PRF 100 | PRF 200 | |
|---|---|---|---|---|---|---|
| Initial weight (g) | 27.64 ± 1.26 a | 34.60 ± 6.20 b | 32.53 ± 3.78 b | 33.01 ± 4.61 b | 32.70 ± 3.11 b | 32.84 ± 2.83 b |
| Final weight (g) | 28.73 ± 0.30 a | 43.26 ± 5.68 c | 37.36 ± 3.98 b | 37.54 ± 5.12 b | 37.07 ± 3.56 b | 36.71 ± 4.66 b |
| Weight gain (g) | 1.26 ± 0.30 a | 8.66 ± 1.20 c | 4.83 ± 1.93 b | 4.53 ± 2.10 b | 4.37 ± 2.17 b | 3.87 ± 2.22 b |
| Food intake (g/mouse/day) |
4.08 ± 0.51 a | 2,76 ± 0.18 b | 3.05 ± 0.34 b | 2.89 ± 0.50 b | 2.61 ± 0.23 b | 2.74 ± 0.56 b |
| Liver (g) | 1.37 ± 0.08 bc | 1.49 ± 0.41 c | 1.09 ± 0.18 a | 1.36 ± 0.15 abc | 1.19 ± 0.17 ab | 1.25 ± 0.08 ab |
| Epididymal fat (g) | 0.67 ± 0.17 a | 2.55 ± 0.60 c | 2.11 ± 0.20 bc | 1.70 ± 0.41 b | 1.93 ± 0.41 b | 1.74 ± 0.77 b |
| Kidney (g) | 0.30 ± 0.03 a | 0.36 ± 0.02 b | 0.31 ± 0.04 a | 0.35 ± 0.03 b | 0.34 ± 0.02 b | 0.34 ± 0.03 b |
| Spleen (g) | 0.08 ± 0.01 a | 0.13 ± 0.02 b | 0.07 ± 0.02 a | 0.09 ± 0.01 a | 0.08 ± 0.02 a | 0.09 ± 0.03 a |
HFD-induced obese mice were orally administered the drug under an HFD for a further 5 weeks. ND, normal diet; HFD, high-fat diet; OR, HFD + 15.6 mg of orlistat; PRF 50, PRF 100, and PRF 200, HFD + 50, 100, and 200 mg of PRF, respectively. The results are expressed as the means ± SDs (n = 7). The values with different letters (a–c) are significantly different (p < 0.05) from each other according to one-way ANOVA and Duncan’s multiple-range test.