Table 1.

Summary of the molecular characteristics of mechanosensitive aGPCRs.

Receptor	Ligand	GPS Cleavage	Mechanical Force	In Vitro/In Vivo Evidence	References
ADGRE2/EMR2	DS, Ab	Dependent	Vibratory shaking	Vibratory urticaria, in vitro cell-based system	[9]
ADGRE5/CD97	CD55	Dependent	Shear stress	Blood flow/animal model	[10]
ADGRG1/GPR56	Collagen III TG2/laminin, Ab	Dependent Dependent	Shear stress N/A	Blood flow/animal model in vitro cell-based system	[12] [51]
ADGRG5/GPR114	N/A	Independent	Vibratory shaking	in vitro cell-based system	[11]
ADGRG6/GPR126	laminin-211	Dependent	Ligand polymerization	Zebrafish model, in vitro cell-based system	[52]
ADGRL1/LPHN1/CIRL	N/A	Independent	Touch, sound, stretch	Drosophila model	[14]
ADGRV1/VLGR1	N/A	N/A	mechanical stretch	in vitro cell-based system	[13]