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(A) Pharmacological treatment of the Cluster A patients (number of patients = 211). Rac-methadone, at the first visit, represented the preferred option. F = female, M = male, TOT = total aggregated data. Patient distribution on drug therapy at recruitment (B) and after 21 months of COVID-19, during the pandemic period. (C) Rac-methadone (MET), LEVO = levomethadone.
