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. 2022 Feb 21;14(2):461. doi: 10.3390/pharmaceutics14020461

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) The QTcF in the double diagnosis patients under maintenance treatments. Levomethadone showed the lowest values in bipolar patients and major depressive disorders (*) vs. other treatments (data significantly different * ANOVA one-way F > 2.5 p < 0.05), and the highest values in the schizophrenia patients, due to the inclusion of one congenital QT case. (B,C) Cardiovascular parameter in the double diagnosis (D.D.) patients under maintenance treatments. HR = heart rate, RR = intervals of the ECG.