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. Author manuscript; available in PMC: 2022 Feb 25.
Published in final edited form as: J Trauma Acute Care Surg. 2021 Feb 1;90(2):274–280. doi: 10.1097/TA.0000000000003000

Figure 3.

Figure 3.

In vivo cerebral microvascular permeability. (A) Representative image of FITC-albumin leakage in the cerebral microcirculation. The microvascular permeability index equals the ratio of mean fluorescence of three separate locations outside the vessel wall (IP) tomean fluorescence of three separate locations within venule (IV). (B) Fluorescein isothiocyanate–albumin leakage in the pial penumbral microcirculation 48 hours after CCI. Compared with untreated injured animals (CCI-VEH), only AT-III reduced post-TBI cerebrovascular albumin leakage (*p < 0.05 vs. CCI-VEH). The box plot contains the median (−) and themean (X). IV, venular intensity;IP, perivenular intensity.