Figure 2.

MMV019721 and MMV084978 induce unique cellular metabolomic profiles in P. falciparum parasites upon drug exposure

Principal-component analysis (PCA) plot of the metabolic profiles of parasites treated with MMV019721 or MMV084978, in comparison to those of antiplasmodial compounds known to target mitochondrial function (atovaquone, ELQ-300, and DSM1, green), folate biosynthesis (pyrimethamine, P218, and WR99210, blue), or ion homeostasis (PfATP4-SJ733, NITD609, or KAF246, cyan) (Allman et al., 2016). PC1 represented 50.6% variance while PC2 represented 20.4% of the variance between all compounds. Principal components were calculated using the log2 fold-change in abundance of 98 soluble metabolites caused by test compounds relative to untreated parasite controls. PCA was conducted with MetaboAnalystR (Chong et al., 2019; Chong and Xia, 2018). See also Figure S3 and Table S4.