Table 2.

Inhibition of PfAcCS WT, T648M and A597V, and HsAcAS by MMV019721 and MMV084978

Parameter	AcAS	MMV019721	MMV084978
IC50 (μM)	WT	0.073 ± 0.004	0.37 ± 0.04
	T648M	18 ± 3.2	>100
	A597V	6.9 ± 1.2	>100
	HsWT	>100	18 ± 1.9
Hill	WT	0.85 ± 0.04	0.85 ± 0.06
	T648M	0.81 ± 0.12	N/Aa
	A597V	0.58 ± 0.05	N/Aa
	HsWT	N/Aa	0.85 ± 0.07

Data presented as mean ± SD.

^aN/A, not applicable.