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. 2022 Feb 21;23(4):2378. doi: 10.3390/ijms23042378

Figure 4.

Figure 4

Ferritin Heavy Chain (FtH1) Ferroxidase Active Site for Iron Entry into the Ferritin Cage. The FtH1 ferroxidase active site. Ferrous (Fe2+) iron enters through the pore-like domains and is delivered to glutamate (Glu) 27 and then to Glu62. Histidine (His) 65 prevents back flow and transfers iron towards the carboxyl group of Glu62. Ferrous iron is then converted into ferric (Fe3+) iron passing via Glu62, Glu107, and glutamine (Gln) 141. All bond lengths are in angstroms (Å). Green chains represent amino acid carbon backbone structures, red represents oxygen groups, and blue represents nitrogen groups. Red FEE) orbs infer iron atoms while purple (O) infers free oxygen ions. Created using PyMOL2 and RCSB PDB: 1FHA.