Table 3.
ROC analysis of PT-INR, platelet counts, and D-dimer for diagnosing DIC or pre-DIC vs. non-DIC.
| DIC/Pre-DIC | Cut-Off Value | Sensitivity | Specificity | AUC | NPV | Odds’ Ratio | |
|---|---|---|---|---|---|---|---|
| PT-INR | DIC | 1.20 | 88.8% | 88.0% | 0.934 | 98.9% | 45.3 |
| DIC + Pre-DIC | 1.11 | 77.9% | 77.9% | 0.848 | 95.7% | 12.5 | |
| PLT (×1010/L) | DIC | 12.0 | 93.6% | 80.0% | 0.925 | 44.1% | 58.8 |
| DIC + Pre-DIC | 16.4 | 76.2% | 76.2% | 0.828 | 34.0% | 10.2 | |
| D-dimer (μg/mL) | DIC | 10.0 | 93.1% | 92.5% | 0.971 | 99.6% | 166.4 |
| DIC + Pre-DIC | 7.8 | 86.4% | 87.0% | 0.930 | 97.9% | 42.5 |
DIC, disseminated intravascular coagulation; Non-DIC, DIC score ≤ 4; Pre-DIC, DIC score 5 or 6; DIC, DIC score ≥ 7 using the Japanese Ministry of Health, Labor and Welfare diagnostic criteria. PT-INR, prothrombin time–international normalized ratio; AUC, area under the curve; NPV, negative predictive value.