Table 3.
Studies with both spontaneous and treatment-induced seroclearance of HBV with incidence of HCC.
| Author | Year | Design | Country | Total (n) | Seroclearance n (%) | Spontaneous n (%) | Treatment Induced n (%) | Male n (%) | Age (yrs) | Cirrhosis at Seroclearance n (%) | HCC in Seroclearance Group n (%) | Mean Follow-Up after Seroclearance |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fattovich [90] | 1998 | Retrospective | Europe | 309 | 32 (10) | 16 (50) | 16 (50) | - | - | - | 1 (3) | - |
| Arase [91] | 2006 | Retrospective | Japan | 5055 | 231 (5) | 156 (68) | 75 (32) | - | - | - | 2 (1) | - |
| Yuen [20] | 2008 | Retrospective | Hong Kong | 298 | 298 (100) | 285 (96) | 13 (4) | 211 (71) | - | - | 7 (2) | - |
| Tong [92] | 2009 | Retrospective | USA | 1200 | 35 (3) | 21 (60) | 14 (40) | - | - | - | 4 (11) | - |
| Moucari [93] | 2009 | Retrospective | Europe | 97 | 28 (29) | 0 | 28 (100) | - | - | - | 0 | - |
| Kim, JH [17] | 2011 | Retrospective | South Korea | 2870 | 96 (3) | 91 (95) | 5 (5) | 77 (80) | 46.4 | 24 (25) | 6 (6) | - |
| Idilman [94] | 2012 | Retrospective | Turkey | 183 | 10 (6) | 0 | 10 (100) | - | - | - | 0 | - |
| Suzuki [95] | 2012 | Retrospective | Japan | 615 | 69 (11) | 0 | 69 (100) | - | - | - | 0 | - |
| Cho [96] | 2014 | Retrospective | South Korea | 2392 | 166 (7) | 149 (90) | 17 (10) | - | - | - | 10 (6) | - |
| Kim, GA [69] | 2014 | Prospective | South Korea | 5409 | 110 (2) | 0 | 110 (100) | 84 (76) | 42 | 34 (31) | 2 (2) | 72 |
| Orito [10] | 2015 | Retrospective | Japan | 602 | 13 (2) | 0 | 13 (100) | - | - | - | 0 | - |
| Lauret [71] | 2015 | Prospective | Spain | 612 | 78 (13) | 56 (72) | 22 (28) | 56 (72) | 51 | 12 | 1 (1)s | - |
| Kim, GA [18] | 2015 | Retrospective | South Korea | 829 | 829 (100) | 724 (87) | 105 (13) | 575 (69) | 52.3 | 98 (12) | 19 (2) | 38.4 |
| Nagaoka [97] | 2016 | Retrospective | Japan | 50 | 50 (100) | 47 (94) | 3 (6) | 45 (90) | 41.5 | - | 2 (4) | 210 |
| Chen [70] | 2016 | Retrospective | Taiwan | 422 | 422 (100) | 312 (74) | 110 (26) | 322 (76) | 50.4 | 5 (1) | 5 (1) | 107 |
| Stelma [98] | 2017 | Prospective | The Netherlands | 92 | 16 (17) | 0 | 16 (100) | 12 (75) | 39.5 | - | 1 (6) | 60 |
| Chi [99] | 2017 | Retrospective | Multicenter | 5872 | 54 (92) | 0 | 54 (100) | 47 (94) | 48 | - | 0 | 19.2 |
| Yip [19] | 2017 | Retrospective | China | 73493 | 4568 (6) | 3715 (81) | 853 (19) | 2874 (63) | - | 839 (18) | 54 (3) | - |
| Alawad [100] | 2019 | Retrospective | USA | 787 | 65 (8) | 19 (29) | 46 (71) | 52 (80) | 49 | - | 0 | 115 |
| Li [101] | 2019 | Retrospective | China | 172 | 172 (100) | 0 | 172 (100) | 135 (78) | 42.6 | - | 1 (1) | 12 |
| Wu [102] | 2019 | Retrospective | China | 1276 | 238 (19) | 0 | 238 (100) | 152 (64) | 36 | - | 0 | 37 |