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. 2022 Jan 20;10(2):155. doi: 10.3390/vaccines10020155

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Profile of liver enzymes during F. hepatica infection. (A,B) Level of glutamate dehydrogenase (GLDH; units/L) in serum during the vaccine trial time-course presented on a log scale. (A) In Trial 1, serum samples were analysed at post-vaccination/pre-challenge with F. hepatica metacercariae (PC), 3 wpi and 16 wpi time-points. (B) In Trial 2, serum samples were analysed at post-vaccination/pre-challenge with F. hepatica metacercariae (PC), 3 wpi, 8 wpi and 16 wpi time-points. (C,D) Level of gamma glutamyl-transferase (GGT; units/L) in serum during the vaccine trial time-course presented on a log scale. (C) In Trial 1, serum samples were analysed at post-vaccination/pre-challenge with F. hepatica metacercariae (PC), 3 wpi and 16 wpi time-points. (D) In Trial 2, serum samples were analysed at post-vaccination/pre-challenge with F. hepatica metacercariae (PC), 3 wpi, 8 wpi and 16 wpi time-points. Data represented at ± standard deviation. G1, control unvaccinated, uninfected; G2, control unvaccinated, infected; G3 and G4, vaccinated, infected.