Table 2.
Metabolites 1 | Chain Length 2 | Identifier 3 | Mean m/z 4 | Exact m/z 5 | Δ 6 | % 7 | p-Value 8 |
---|---|---|---|---|---|---|---|
Acetylcarnitine | C2 | M204T119 | 204.123 | 204.1230 | 0.0 | 0.70 | 4.6 × 10−4 |
Propionylcarnitine | C3 | M218T126 | 218.139 | 218.1387 | −1.4 | 0.67 | 3.5 × 10−12 |
Butyrylcarnitine | C4 | M232T167_1 | 232.155 | 232.1543 | −3.0 | 0.64 | 2.8 × 10−7 |
(Iso)valerylcarnitine | C5 | M246T226 | 246.170 | 246.1700 | 0.0 | 0.51 | 1.6 × 10−19 |
Hexanoylcarnitine | C6 | M260T289 | 260.186 | 260.1856 | −1.5 | 0.69 | 8.7 × 10−8 |
Heptanoylcarnitine | C7 | M274T349 | 274.201 | 274.2013 | 1.1 | 0.53 | 2.6 × 10−15 |
Octanoylcarnitine | C8 | M288T405 | 288.217 | 288.2169 | −0.3 | 0.55 | 7.4 × 10−12 |
Nonanoylcarnitine | C9 | M302T456_2 | 302.232 | 302.2326 | 2.0 | 0.69 | 3.6 × 10−9 |
Decenoylcarnitine | C10:1 | M314T459 | 314.232 | 314.2326 | 1.9 | 0.59 | 8.8 × 10−3 |
Decanoylcarnitine | C10 | M316T504 | 316.248 | 316.2482 | 0.6 | 0.46 | 7.1 × 10−8 |
Hydroxyhexadecadiencarnitine | C16:2-OH | M412T568 | 412.304 | 412.3057 | 4.1 | 0.64 | 2.7 × 10−4 |
Tetradecadiencarnitine | C14:2 | M368T572 | 368.279 | 368.2795 | 1.4 | 0.55 | 7.1 × 10−4 |
Dodecanoylcarnitine | C12 | M344T573 | 344.279 | 344.2795 | 1.5 | 0.59 | 6.4 × 10−6 |
Hydroxyhexadecenoylcarnitine | C16:1-OH | M414T588 | 414.321 | 414.3214 | 1.0 | 0.64 | 4.0 × 10−14 |
Tetradecenoylcarnitine | C14:1 | M370T591 | 370.295 | 370.2952 | 0.5 | 0.59 | 1.3 × 10−7 |
Hexadecadienoylcarnitine | C16:2 | M396T601 | 396.311 | 396.3108 | −0.5 | 0.55 | 5.8 × 10−7 |
Hydroxyhexadecanoyl carnitine | C16-OH | M416T606 | 416.337 | 416.3371 | 0.2 | 0.79 | 3.7 × 10−8 |
Tetradecenoylcarnitine | C14 | M372T608 | 372.311 | 372.3108 | −0.5 | 0.64 | 2.9 × 10−8 |
Linolenylcarnitine | C18:3 | M422T611 | 422.327 | 422.3265 | −1.2 | 0.69 | 1.9 × 10−6 |
Hydroxyoctadecanoylcarnitine | C18-OH | M442T617 | 442.353 | 442.3527 | −0.7 | 0.65 | 2.3 × 10−10 |
Linoleylcarnitine | C18:2 | M424T628 | 424.343 | 424.3421 | −2.1 | 0.78 | 1.9 × 10−4 |
Unidentified | Na | M307T132 | 307.122 | NA | NA | 1.59 | 3.6 × 10−10 |
1 Putative identities according to MSI [13], 2 number of carbons, saturations, and alcohols on the ester-group on the acylcarnitines, 3 specific identifier for each chromatographic peak, including mass and retention time, 4 mean measured accurate mass for [H]+ over all samples, 5 theoretical monoisotopic mass 6 ppm difference between measured and theoretical mass, 7 % of median of the normalized peak intensities of the intoxication group divided by the positive control group including both training and validation set, and 8 Bonferroni-corrected p-values for the log transformed normalized intensities in the intoxication group vs. positive controls.