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. 2022 Jan 25;14(2):276. doi: 10.3390/pharmaceutics14020276

Figure 7.

Figure 7

Scale-up of nanoformulations. (A) Size and PDI of the particles obtained at varied PLGA concentrations and fixed total flow rate of 8 mL/min. (B) Particle size and size distribution of placebo particles obtained applying different TFRs by using an initial PLGA concentration of 20 wt% in EtOAc. (C) Comparison of the particles obtained with the scaled-up indirect inline technology versus particles achieved at a higher processed volume and lower total sonication time of direct probe batch method.