Table 3.

Process parameters evaluated for the inline sonication method scale-up.

Inline Sonication
Exp. No.	API	DP Solution	DP Flowrate (mL/min)	CP Solution	CP Flowrate (mL/min)	EP Solution	EP Flowrate (mL/min)	Throughput (g/h)
3	-	4.5 wt% PLGA, 85.9 wt% EtOAc, 9.6 wt% DMSO	2	2 wt% PVA	6	MilliQ water	60	5
4	-	8.3 wt% PLGA, 74.3 wt% EtOAc, 5.7 wt% DMSO	2	2 wt% PVA	6	MilliQ water	60	10
5	-	14.1 wt% PLGA, 56.2 wt% EtOAc, 29.7 wt% DMSO	2	2 wt% PVA	6	MilliQ water	60	19
6	-	14.1 wt% PLGA, 56.2 wt% EtOAc, 29.7 wt% DMSO	4	2 wt% PVA	12	MilliQ water	120	38
7	Placebo	14.1 wt% PLGA, 56.2 wt% EtOAc, 29.7% DMSO	8	2 wt% PVA	24	MilliQ water	240	76
8	Ritonavir	13.9 wt% PLGA, 55.4 wt% EtOAc, 1.5 wt% ritonavir, 29.2 wt% DMSO	8	2 wt% PVA	24	MilliQ water	240	84
9	Celecoxib	13.9 wt% PLGA, 55.4 wt% EtOAc, 1.5 wt% ritonavir, 29.2 wt% DMSO	8	2 wt% PVA	24	MilliQ water	240	84