AD	Alzheimer’s disease
ADE	amyloid degrading enzymes
AEP	asparagine endopeptidase
AKT/GSK	3β: protein kinase B/glycogen synthase kinase-3beta
AMPK/SIRT1	Adenosine monophosphate-activated protein kinase [AMPK]/NAD-dependent deacetylase sirtuin-1 [SIRT1]
AP-1	activator protein-1
ARE	antioxidant response element
ARG1	Arginase-1
Aβ	amyloid-beta
BBB	blood-brain barrier penetration
CB2R	cannabinoid receptor 2
CD206	macrophage mannose receptor
CNTFRα	ciliary neurotrophic factor receptor alpha
COX2	Cyclooxygenase-2
CSFs	colony-stimulating factors
CYP450	cytochrome P450
ERK1/2	Extracellular signal-regulated kinase
GABA-B	γ-aminobutyric acid type B
GPCRs	G protein-coupled receptors
HO-1	heme oxygenase-1
IDE	insulin-degrading enzyme
IFNs	interferons
IKK	IκB kinase
IL	interleukins
INF-γ/LPS	interferon-gamma combined with lipopolysaccharide
iNOS	Inducible nitric oxide synthase
IκB	NF-κB inhibitor
JAK-STAT	Janus kinase signal transducer and activator of transcription
JNK	c-Jun N-terminal kinase
logS	high solubility
LOO-CV	leave-one-out cross-validation
LPS	Lipopolysaccharide
MAPK	mitogen-activated protein kinase
MCP-1	monocyte chemoattractant protein-1
MS	Multiple sclerosis
mTOR	mammalian target of rapamycin
MW	molecular weight
NDs	neurodegeneration diseases
NEP	neprilysin
NF-κB	nuclear factor-kappa-B
NFT	neurofibrillary tangles
NLRP3	NLR family pyrin domain containing 3
NLRs	nucleotide-binding oligomerization domain [nod]-like receptors
NO	nitric oxide
NOX2	nicotinamide adenine dinucleotide phosphate [NADPH] oxidase-2
Nrf2	nuclear factor erythroid 2-related factor 2
P-gp	P-glycoprotein
Pa:Pi	active, inactive ratio
PASS	predict the activity spectra of substances
PD	Parkinson’s disease
PGE2	prostaglandin E2
PI3K/Akt	phosphatidylinositol-3-Kinase and Protein/Kinase B
PIKKs	phosphatidylinositol 3-kinase-related kinase
PPARs	Peroxisome proliferator-activated receptors
PRRs	pattern-recognition receptors
ROS	reactive oxygen species
SMILES	simplified molecular-input line-entry system
SRC	non-receptor protein tyrosine kinase
STATs	signal transducer and activator of transcription
TGF-β	transforming growth factor-beta
TLRs	toll-like receptors
TNF-α	tumor necrosis factor-α
TREMs	triggering receptor expressed on myeloid cells
TRP	potential transient receptors
WBC	white blood cells
α-SYN	alpha-synuclein