FIG. 3.

The Tsc13p and SC2 proteins are members of an evolutionarily conserved family of proteins. (a) Alignment of rat, human, Arabidopsis thaliana (arab), Schizosaccharomyces pombe (pombe), and S. cerevisiae (cere) homologs. The tsc13-1 mutant allele has a substitution of lysine for the highly conserved glutamine at residue 81 of the S. cerevisiae protein (marked with an asterisk). (b) All of the Tsc13p/SC2 protein homologs have similar hydrophilicity profiles. Segments of the proteins with the potential to span the membrane are indicated in black.