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. 2022 Feb 9;15(2):210. doi: 10.3390/ph15020210

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The location of the endocannabinoid system on the skin. A, hair follicle; B, sebaceous gland; C, sweat gland; D, nerve; E, blood vessels; F, keratinocytes; G, Langerhans cell (immunocyte); H, melanocytes. The figure shows the location of the two main ECBs, 2-arachidoynyl-glycerol (2-AG) and anandamide (AEA), and of several ECB receptors, including the main cannabinoid receptors CB1R and CB2R, several transient potential ion channel receptors (TRPs) and peroxisome proliferator-activated receptors (PPARs) [26].