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. 2022 Feb 11;11(4):495. doi: 10.3390/plants11040495

Figure 2.

Figure 2

Bioavailability radar of identified compounds based on the physicochemical indices ideal for oral bioavailability. LIPO, lipophilicity: −0.7 < XLOGP3 < þ 5; SIZE, molecular size: 150 g/mol < molecular weight < 500 g/mol; POLAR, polarity: 20 Å2 < TPSA (Topological Polar Surface Area) < 130 Å2; INSOLU, insolubility: 0 < Log S (Insolubility in water: ESOL) < 6; INSATU, Insaturation: 0.25 < Fraction of carbons in the sp3 hybridization < 1; FLEX, flexibility: 0 < the number of rotatable bonds < 9. The colored zone is the suitable physicochemical space for oral bioavailability.