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Relative weights of unbinding mechanisms for WT insulin and the A10 Ile→Val and B13 Glu→Gln mutations.
| Pathway | WT (%) | A10 (%) | B13 (%) |
|---|---|---|---|
| PW1 | 11.2 | 4.3 | 19.0 |
| PW1a | 11.2 | 7.8 | 16.0 |
| PW2 | 16.3 | 16.7 | 14.1 |
| PW3 | 12.6 | 8.7 | 7.1 |
| PW4 | 13.7 | 18.4 | 26.7 |
| PW4a | 35.0 | 44.2 | 17.2 |
