Table 2.

Diagnostic performance of the metabolite biomarker panel for the classification of patients with laryngeal cancer and healthy individuals.

	Training set			Leave one out cross-validation
	AUC (95% CI)	Sensitivity	Specificity	AUC (95% CI)	Sensitivity	Specificity
Arg	0.7533 (0.6449–0.8617)	0.6923	0.7925	0.7291 (0.6224–0.8358)	0.6923	0.7736
Pro	0.7005 (0.5882–0.8128)	0.6923	0.6792	0.6681 (0.5546–0.7817)	0.6667	0.6604
C26	0.7467 (0.6463–0.8472)	0.6154	0.8302	0.6686 (0.5551–0.7821)	0.6154	0.8302
Orn/Cit	0.6713 (0.5562–0.7863)	0.5641	0.7925	0.6251 (0.5082–0.7419)	0.5641	0.7736
C18:1-OH	0.7937 (0.7096–0.8777)	0.6410	0.9245	0.6207 (0.5036–0.7379)	0.6410	0.9245
Five-biomarker panel	0.9308 (0.8782–0.9834)	0.8974	0.8868	0.8921 (0.8198–0.9644)	0.8974	0.8302

Arg = arginine, C18:1-OH = 3-hydroxy-octadecenoylcarnitine, C26 = hexacosanoic carnitine, Cit = citrulline, Orn = ornithine, Pro = proline.