Table 3.
Multivariable adjusted models (95% confidence intervals) for the risk of sarcopenia.
| Model | DII, OR (95% Cl) | p-Trend | |||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
| Sarcopenia | |||||
| Model 1 | 1 | 1.00 (0.31, 3.23) | 0.38 (0.09, 1.59) | 5.33 (1.84, 15.47) | 0.012 |
| Model 2 | 1 | 1.24 (0.30, 5.06) | 0.45 (0.08, 2.45) | 7.22 (1.95, 26.80) | 0.009 |
| Model 3 | 1 | 1.09 (0.23, 5.04) | 0.52 (0.08, 3.41) | 9.59 (1.69, 54.42) | 0.031 |
| Muscle Mass (ASMI a) | |||||
| Model 1 | 1 | 0.63 (0.21, 1.89) | 0.42 (0.13, 1.38) | 4.23 (1.55, 11.55) | 0.022 |
| Model 2 | 1 | 0.69 (0.18, 2.73) | 0.48 (0.11, 2.23) | 5.48 (1.51, 19.87) | 0.018 |
| Model 3 | 1 | 0.63 (0.15, 2.72) | 0.51 (0.09, 2.79) | 5.77 (1.06, 31.35) | 0.106 |
| Muscle Function (Handgrip strength b) | |||||
| Model 1 | 1 | 0.53 (0.20, 1.44) | 0.33 (0.12, 0.97) | 2.00 (0.77, 5.18) | 0.432 |
| Model 2 | 1 | 0.53 (0.18, 1.55) | 0.33 (0.10, 1.06) | 1.87 (0.67, 5.21) | 0.481 |
| Model 3 | 1 | 0.48 (0.15, 1.58) | 0.23 (0.06, 0.89) | 1.26 (0.33, 4.83) | 0.804 |
Odds ratios and 95% confidence interval were estimated with logistic regression models with different levels of adjustment. Model 1 was unadjusted for any covariate. Model 2 was adjusted for sex (male/female), age (continuous) and Body mass index (BMI < 18.5 kg/m2, 18.5 ≤ BMI ≤ 24 kg/m2, BMI > 24 kg/m2), smoking status (current/former/never), alcohol consumption (no/moderate/regular). Model 3 was additionally adjusted for nutritional status (malnutrition: PG-SGA ≥ 4, normal nutritional status: PG-SGA < 4), disease activity (active phase: CDAI ≥ 150, remission phase: CDAI < 150), total energy intake, disease duration, Montreal Classification-Location (L1: terminal ileum, L2: colon, L3: ileocolon, and L4: involving the upper gastrointestinal tract) and Montreal Classification-Behavior (B1: non-stricturing and non-penetrating, B2: stricturing, and B3: penetrating). The trend is calculated with the quartile number as a continuous variable. a ASMI (appendicular skeletal muscle mass index, ASMI < 7.0 kg/m2 for male, ASMI < 5.7 kg/m2 for female, via BIA) b Handgrip strength < 28 kg for male, handgrip strength < 18 kg for female.