Table 2.

Adhesion molecules required for T lymphocyte homing. Lymphocyte homing to lymph nodes, Peyer’s patches in the gut and lungs in IAV infection require a unique set of adhesion molecules that aid in tethering, rolling and arrest of lymphocytes for cell trafficking. PNAd; peripheral lymph node addressin, CCR7; chemokine receptor 7, CCL19/21; chemokine ligand 19/21, LFA-1; leukocyte function-associated antigen 1, ICAM-1; intercellular cell-adhesion molecule-1, MAdCAM-1; mucosal addressin cell adhesion molecule 1, PSGL-1; P-selectin glycoprotein ligand 1, IAV; influenza A virus, VLA-4; very late antigen-4, Mac-1; macrophage antigen-1, VCAM-1; vascular cell-adhesion molecule-1.

Location	Selectins	Selectin Ligands	Chemokine Receptors and Ligands	Integrins	Integrin Ligands
Peripheral lymph nodes	L-selectin [82]	PNAd [83]	CCR7, CCL19, CCL21 [57,84,85]	LFA-1 [86]	ICAM-1, ICAM-2 [86,87]
Mesenteric lymph node	L-selectin [82]	MAdCAM-1, PNAd [83,88]	CCR7, CCL19, CCL21 [89]	α4β7, LFA-1 [90,91]	MAdCAM-1 [90]
Peyer’s patches in gut mucosa	P-selectin 1, L-selectin [92]	PSGL-1, MAdCAM-1 [93]	CCR7, CCL21 [94]	α4β7, LFA-1 [91,95]	MAdCAM-1 [95]
Lungs in IAV infection 1	L-selectin [2]	Not known	CXCR1, CXCR3, CCR4, CCR5, CXCR6 [96]	VLA-4, LFA-1 [96]	VCAM-1, ICAM-1 [96]

¹ Required during inflammation/infection.