Substrates of ADAM17 in humans and mice and their functions within the immune system. TLR; Toll like receptor, IL-6/15/23R; interleukin 6/15/23 receptor, IL-1RII; interleukin 1 receptor II, TNFR-I/II; tumour necrosis factor receptor I/II, TNFα; tumour necrosis factor alpha, IL-1β; interleukin 1 beta, CD154/89/44/16; cluster of differentiation 154/89/44/16, ICAM-1; intercellular adhesion molecule 1, VCAM-1; vascular adhesion molecule 1, JAM-A; junction adhesion molecule A, EGF; epidermal growth factor, LAG-3, lymphocyte activation gene 3, TIM-3/1/4; T cell immunoglobulin and mucin domain 3/1/4, ACE2; angiotensin converting enzyme 2.