Table 3.

Substrates of ADAM17 in humans and mice and their functions within the immune system. TLR; Toll like receptor, IL-6/15/23R; interleukin 6/15/23 receptor, IL-1RII; interleukin 1 receptor II, TNFR-I/II; tumour necrosis factor receptor I/II, TNFα; tumour necrosis factor alpha, IL-1β; interleukin 1 beta, CD154/89/44/16; cluster of differentiation 154/89/44/16, ICAM-1; intercellular adhesion molecule 1, VCAM-1; vascular adhesion molecule 1, JAM-A; junction adhesion molecule A, EGF; epidermal growth factor, LAG-3, lymphocyte activation gene 3, TIM-3/1/4; T cell immunoglobulin and mucin domain 3/1/4, ACE2; angiotensin converting enzyme 2.

Role within the Immune System	ADAM17 Substrate
Pattern recognition	TLR2 [122], TLR4 [123]
Inflammation	IL-6R [124], IL-15R [125], IL-23R [126], IL-1RII [127], TNFR-I [117], TNFR-II [128], TNFα [115], Lymphotoxin-αβ [129], IL-1β, [130], CD154 [131], CD89 [132], 4-1BB [133]
Leukocyte adhesion and migration	ICAM-1 [134], VCAM-1 [135], L-selectin [117], CD44 [136], JAM-A [137]
T cell activation, proliferation and exhaustion	LAG-3 [119], TIM-3 [138]
Natural killer cell toxicity	CD16 [139]
Viral cell entry	ACE2 [140], TIM-1, TIM-4 [141]