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. 2022 Feb 11;9:791423. doi: 10.3389/fmed.2022.791423

Table 4.

Mixed linear regression analysis of hemodynamic parameters dependent on arterial and mixed oxygen partial pressures, independent of FiO2.

Dependent variable Factor Mean change 95% confidence interval p-value
Univariable analysis:
Mean pulmonary artery pressure, mmHg PaO2 −0.083 −0.100 −0.065 <0.001*
Pulmonary vascular resistance, WU −0.011 −0.016 −0.006 <0.001*
Cardiac Index, l/min/m2 −0.003 −0.005 −0.001 0.001*
Pulmonary artery wedge pressure, mmHg −0.002 −0.008 0.004 0.494
Mean pulmonary artery pressure, mmHg PmvO2 −2.668 −3.187 −2.149 <0.001*
Pulmonary vascular resistance, WU −0.474 −0.620 −0.328 <0.001*
Cardiac Index, l/min/m2 −0.021 −0.070 0.029 0.411
Pulmonary artery wedge pressure, mmHg −0.024 −0.205 0.158 0.799
Multivariable analysis:
Mean pulmonary artery pressure, mmHg PaO2 −0.020 −0.053 0.014 0.257
PmvO2 −2.400 −3.451 −1.348 <0.001*
Age −0.132 −0.260 −0.003 0.044*
Female −0.211 −4.682 4.260 0.926
CTEPH vs. PAH 1.392 −3.417 6.201 0.571
Qs/Qt −0.108 −0.323 0.106 0.323
KCO −0.113 −0.236 0.010 0.071
Pulmonary vascular resistance, WU PaO2 0.008 −0.002 0.018 0.097
PmvO2 −0.703 −1.011 −0.395 <0.001*
Age −0.020 −0.051 0.010 0.193
Female 0.732 −0.333 1.796 0.178
CTEPH vs. PAH 1.047 −0.100 2.194 0.074
Qs/Qt −0.007 −0.066 0.052 0.827
KCO −0.029 −0.059 0.000 0.052
Cardiac index, l/min/m2 PaO2 −0.007 −0.011 −0.004 <0.001*
PmvO2 0.154 0.049 0.259 0.004*
Age −0.009 −0.015 −0.002 0.007*
Female −0.048 −0.268 0.172 0.670
CTEPH vs. PAH −0.340 −0.578 −0.103 0.005*
Qs/Qt 0.010 −0.006 0.026 0.224
KCO 0.000 −0.006 0.006 0.988
Pulmonary artery wedge pressure, mmHg PaO2 −0.008 −0.021 0.004 0.590
PmvO2 0.189 −0.192 0.571 0.330
Age 0.029 −0.012 0.071 0.170
Female 0.121 −1.322 1.565 0.870
CTEPH vs. PAH −0.089 −1.642 1.465 0.911
Qs/Qt −0.030 −0.105 0.045 0.435
KCO 0.011 −0.028 0.051 0.590

Multivariable mixed regression models displaying the mean change (coefficient) with 95% CI of resting hemodynamic variables dependent on multiple factors. This model is adjusted for the arterial partial pressure of oxygen (PaO2) independent of FiO2, due to its strong collinearity with FiO2 (variance inflation factor >10). CTEPH, chronic thromboembolic pulmonary hypertension; KCO, carbon monoxide transfer coefficient; PAH, pulmonary arterial hypertension; Qs/Qt, right-to-left shunt fraction; statistically significant values (p < 0.05) are denoted with *.