Table 1.
The designed groups and their treatment.
| Group I (Control): | Normal control rats received 0.2 mL saline (i.p.) injection for 10 days. |
| Group II (Sham group): | Rats were given a fake operation and received 0.2 mL saline (i.p.) injection for 10 days. |
| Group III (VINCA S): | Sham-treated rats received a single dose of VINCA (120 mg base/kg in a vehicle (1% carboxymethyl cellulose)) orally [34]. |
| Group IV (VINCA M): | Sham-treated rats received multiple oral doses of VINCA (30 mg base/kg) once daily for 6 days [34]. |
| Group V (PTZ S): | Sham-treated rats received a single dose of PTZ (160 mg/kg, i.p.) [57]. |
| Group VI (PTZ M): | Sham-treated rats received multiple doses of PTZ (40 mg/kg, orally) twice daily for 10 days [57]. |
| Group VII (VINCA S + PTZ S): | Sham-treated rats received a single dose of VINCA (120 mg base/kg) orally [34], and a single dose of PTZ (160 mg/kg) by (i.p.) injection [57]. |
| Group VIII (VINCA M + PTZ M): | Sham-treated rats received multiple doses of VINCA (30 mg base/kg, orally) once daily for 6 days [34], together with multiple doses of PTZ (40 mg/kg, orally) twice daily for 10 days [57]. |
| Group IX (IRI): | IRI rats received 0.2 mL saline by (i.p.) for 10 days. |
| Group X (IRI + VINCA S): | IRI treated rats received a single dose of VINCA (120 mg base/kg, orally) [34]. |
| Group XI (IRI + VINCA M): | IRI treated rats received multiple doses of VINCA (30 mg base/kg) once daily for 6 days orally [34]. |
| Group XII (IRI + PTZ S): | IRI treated rats received a single dose of PTZ (160 mg/kg, i.p.) [57]. |
| Group XIII (IRI + PTZ M): | IRI treated rats received multiple doses of PTZ (40 mg/kg, orally) twice daily for 10 days [57]. |
| Group XIV (IRI + VINCA S + PTZ S): | IRI treated rats received single dose of VINCA (120 mg base/kg) orally [34], together with a single dose of PTZ (160 mg/kg, i.p.) [57]. |
| Group XV (IRI + VINCA M + PTZ M): | IRI treated rats received multiple oral doses of VINCA (30 mg base/kg) once daily for 6 days [34], together with multiple oral doses of PTZ (40 mg/kg) twice daily for 10 days [57]. |
| Group XVI (IRI + Montelukast): | IRI treated rats were received single dose of Montelukast (10 mg/kg, i.p.) [50], used as a positive control group. |