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. 2022 Jan 21;58(2):165. doi: 10.3390/medicina58020165

Table 2.

Most important findings in multimodal imaging of PICCPs.

MEWDS (Figure 1) APMPPE (Figure 2) MFC (Figure 3) SC (Figure 4)
ICGA Intermediate-late hypofluorescence Early to late hypofluorescence Early to late hypofluorescence (scars and new lesions) Hypofluorescence with perilesional hyperfluorescence
BL-FAF Hyperautofluorescence of acute lesions Hyperautofluorescence in active lesions/hypofluorescence of severe acute and atrophic lesions Hyperautofluorescence (active lesions) Hypoautofluorescence (atrophic lesions/scars) Active: Hypoautofluorescence surrounded by hyperautofluorescent halo
Semi-Active: linear hypoautofluorescence around hyperautofluorescent lesion
Inactive: Hypoautofluorescence
SD-OCT Loss of photoreceptor OS
Interruption and/or damage to IS/OS line
Thickening and denaturation of outer retina (hyperreflective area occupying the outer retina) Loss of photoreceptors OS/Interruption and/or damage to IS/OS line atrophic lesions/ICNV Hyperreflective accumulations in the outer retina/ICNV
OCT-A Absent or subtle signs of choriocapillaris drop-out Patchy choriocapillaris drop-out Patchy Choriocapillaris drop-out/ICNV Geographic areas of choriocapillaris drop-out/ICNVs
FA Subtle early to late hyperfluorescence Early hypofluorescence/late hyperfluorescence (staining and pooling) in severe non-perfusion Early hypofluorescence/late hyperfluorescence of scared-atrophic lesions
No FA signs of new lesions
Scars/atrophy: early hypofluorescence and late hyperfluorescence (window defect) surrounded by late more hyperfluorescent rim, if lesions are progressing

BL-FAF = blue light fundus autofluorescence. ICGA = indocyanine green angiography. SD-OCT = spectral domain optical coherence tomography. OCT-A = OCT angiography FA = fluorescein angiography. ICNVs = inflammatory choroidal neovessels IS/OS = inner/outer segment line.