Table 4.
EGFR-targeted PDT performed with anti-EGFR peptides conjugated with carrier molecules.
| Targeting Agent | PS | Cargo | In Vitro studies | In Vivo studies | Ref. |
|---|---|---|---|---|---|
| YHWYGYTPQNVI | Silicon phthalocyanine Pc4 | Gold nanoparticles | 9L.E29 rat glioma cancer cells, engineered to overexpress EGFR | Human glioma (Gli36D5) cells in mice | [112] |
| CYHWYGYTPQNVI | Silicon phthalocyanine Pc4 | PEG (poly(ethylene glycol))-PCL (poly(ɛ-caprolactone) micelles | A431, MCF-7, SCC-15, | SCC-15 cells in SCID mice | [113,114,115] |
| YHWYGYTPQNVIGGGGC | Chlorin e6 (Ce6) | Methoxypoly(ethylene glycol)/poly(ε-caprolactone) (mPEG–PCL) | HCT-116, SW620 | CT-116 and SW620 cells in BALB/c athymic (nut/nut) mice | [116] |
| FITC-βAAEYLRK | Zinc phthalocyanine C11Pc | Gold nanoparticles | A549, HEK293 | [117] | |
| LARLLT | 5-aminolevulinic acid (ALA) (prodrug of protoporphyrin IX) | Dendrimer | MDA-MB-231 | [118] |