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p62-dependent mTORC1 activation. Under amino acid-rich conditions, lysosomal p62 binds to Rags and promotes the assembly of active Rag heterodimers, which, in turn, recruit mTORC1 to lysosomes and promote its activation. Additionally, p62 recruits TRAF6, which promotes mTORC1 polyubiquitination, leading to induction of mTORC1 signaling.
