Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 18;23(4):2290. doi: 10.3390/ijms23042290

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Role of lysosomes in human hematopoietic stem cells (HSCs) fate decisions. In quiescent HSCs, enhanced TFEB activity promotes catabolic pathways and lysosome-mediated degradation of membrane receptor involved in the response to mitogen signals, contributing to maintenance of a dormant state. Upon activation, MYC antagonizes TFEB activity, leading to expression of cell cycle, biosynthesis, and mitochondria-related genes, allowing cells to respond to mitogen stimuli by activation of anabolic pathways and subsequent cell cycle re-entry.