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. 2022 Feb 11;9:797826. doi: 10.3389/fcell.2021.797826

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Copyright © 2022 Yang, Li, Cheng, Zhou, Shen, Zhao and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of CDK1 inhibits the migration and promotes the apoptosis of EC cells (A). High expression of CDK1 protein was closely related to the poor prognosis of EC patients (p < 0.05). The cancer proteome atlas (https://www.tcpaportal.org/tcpa/survival_analysis.html) (B). The CCK-8 showed that the IC50 of Ro 3306 on Ishikawa cells was 6.97 μmol/L (C,D). The scratch test revealed that compared with control group, cells treated with 5 μM or 10 μM Ro 3306 showed significantly increased gap size of oh (E,F). The transwell experiment revealed that compared with control group, cells treated with 5 μM or 10 μM Ro 3306 showed significantly decreased invasion cell numbers (G,H). Detection of apoptosis of Ishikawa cells treated with 5 μM or 10 μM Ro 3306 by flow cytometry. **p < 0.01, compared with control.