Figure 2.

Compounds regulating adipogenesis through epigenetic modification. This figure describes the key components of the epigenetic machinery and its regulation by selected epigenetic compounds. Cellular and molecular mechanisms by which epigenetic compounds might mediate the prevention of obesity through regulating adipogenesis and eventually have an influence on insulin sensitivity and energy homeostasis. This figure summarizes epigenetic regulation in debating obesity, and their potential regulation by epigenetic compounds. Almost all compounds will affect energy expenditure. Abbreviations: DNMT, DNA methyl transferase; PRC2, poly-comb repressive complex 2; HAT, histone acetyltransferase; HDAC, histone deacetylase; HDM, histone demethylase; ILs, interleukins.